Ramsbottom United will be hoping to jump from fourth to second in the Vodkat Premier Division with a home win against struggling Atherton LR.
Padiham, currently 12th, travel to leaders Newcastle Town, while 13th-placed Nelson host second bottom Ashton Athletic at Victoria Park.
Colne, 15th, entertain second-placed New Mills at Holt House with Bacup Borough, 16th, travelling to Glossop North End.
Barnoldswick Town, currently second in the Vodkat First Division and six points behind leaders Stone Dominoes, will be bidding to strengthen their promotion challenge with victory at mid-table Atherton Colleries.
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