Police were asking people to find alternative routes as they dealt with an incident in Padiham.
The road traffic collision had closed Slade Lane in the area.
Lancashire Fire and Rescue said two fire engines from Hyndburn and Earby attended a two-vehicle collision on Barrowford Road after 4.20pm.
Four casualties were assessed by firefighters, with one casualty extricated from their vehicle. Crews used Holmatro equipment at this incident. They currently remain in attendance.
Updates to follow
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