Former world number one Caroline Wozniacki crashed out and French Open champion Maria Sharapova faces a hectic schedule if she is to be champion again after being frustrated by the weather.
But on the second Monday of the championships, Eugenie Bouchard, Sabine Lisicki and Petra Kvitova all stayed on course at Wimbledon.
Canadian live-wire Bouchard secured a place in the quarter-finals by beating Alize Cornet under the roof on Centre Court, while rain thundered down outside at the All England Club.
Cornet had defeated world number one Serena Williams in the third round on Saturday, but she could not repeat the feat as 20-year-old Bouchard stayed on course for a third straight grand slam semi-final appearance with a battling 7-6 (7/5) 7-5 victory.
"The main thing is the confidence I have added since the beginning of the year. I believe in myself. Every match I play, I believe I can win," said the 2012 Wimbledon junior champion.
Bouchard's next task will come against Sharapova, the 2004 Wimbledon champion, or Angelique Kerber.
Their match, the third scheduled for Court One, was carried over until Tuesday due to earlier rain delays. Tournament officials decided shortly before 8pm there was a significant chance of it not finishing before nightfall following the conclusion of Grigor Dimitrov's victory over Leonardo Mayer.
It means Sharapova or Kerber face the daunting possibility of playing in the fourth round on Tuesday, the quarter-finals on Wednesday, and the semi-finals on Thursday, before taking a day off prior to Saturday's final.
German Lisicki, last year's runner-up, has now won three consecutive matches for the first time anywhere this year.
The 19th seed was first up on Court One in a third-round match against 11th seed Ana Ivanovic which was held over from Saturday, when she led the Serbian 6-4 1-1 as bad light halted play.
After she survived a second-set slump to win through 6-4 3-6 6-1, Lisicki said: "I came back and was more focused, I was serving better and I used my chances.
"With her, you have to be ready for every single point. If you have a chance you have to use it, otherwise it can be gone in no time and you might regret not having another chance."
Following a couple of hours' rain delay during the afternoon, Wimbledon's 2012 runner-up Agnieszka Radwanska was another leading seed to be knocked out, losing in straight sets to Russian Ekaterina Makarova on Court Three.
The number four seed, once ranked second in the world, resumed 6-3 5-0 down just after 7pm after rain forced the players off.
The delay did nothing to reverse the momentum of the match, as Makarova, the world number 22, quickly closed out victory with another break of serve.
Kvitova, the 2011 champion, defeated China's Shuai Peng 6-3 6-2, and the Czech will take on compatriot Barbora Zahlavova Strycova next.
After knocking out five-time champion Venus Williams in the previous round, Kvitova intends to just focus on getting the job done again when she tackles a player she knows well.
"Barbora is playing not like everyone here, she is really going for the volleys and playing a different game, so that is what I need to be focused on," said Kvitova.
Zahlavova Strycova followed up her win against number two seed Li Na by reaching her maiden grand slam quarter-final with a 6-2 7-5 victory over Wozniacki.
The 28-year-old, who almost walked away from the sport in February 2013 when she was banned after testing positive for the stimulant sibutramine, said: "I saw some other stuff in my six months off and I enjoy tennis much more now."
Wozniacki, meanwhile, will now focus her attention on the run-up to the US Open.
"I played really well in the first week here, today unfortunately it wasn't as good, but I can take a lot with me and bring to the hard-court season," said the Dane.
Next for Lisicki will be Kazakhstan's Yaroslava Shvedova who was expecting to be back on Court 12 on Monday morning to resume her tussle with 19-year-old American Madison Keys.
But Keys retired from the match, in which she trailed 7-6 (9/7) 6-6, because of a thigh injury she was unable to run off in practice.
In a fourth-round all-Czech battle, Lucie Safarova won out 6-0 6-2 against qualifier Tereza Smitkova and will face Russian Makarova next, for a place in the semi-finals.