Phil Jagielka has been ruled out of England's friendly against Denmark next week with a hamstring injury.
Roy Hodgson will later today reveal his squad for next Wednesday's Wembley game.
But the Everton defender will not be among those named, and will also miss Saturday's Barclays Premier League match against West Ham at Goodison Park.
Toffees boss Roberto Martinez said: "Phil has felt his hamstring over the last couple of days and will be missing at the weekend and for England."
Martinez added: "I don't think it will be a long-term injury, but Phil will be missing for a couple of weeks."