Adele has wowed US music fans for two years running and set a record, with her 2011 album 21 becoming the nation's top seller in 2012 as well.
The British songstress' feat, according to 2012 sales figures released by Nielsen SoundScan, is a first in the SoundScan era.
Adele sold 4.4 million copies of the album in 2012 after selling 5.8 million in 2011. She crossed the 10 million threshold in November and was rivalled only by Taylor Swift, whose Red was second on the list with 3.1 million albums sold.
Swift led a record five country artists into the top 10 last year.
Gotye scored the year's top-selling song with Somebody That I Used To Know, featuring Kimbra. The song was downloaded a record 6.8 million times.
If Adele's album sales continue apace in 2013, 21 will move into the top 10 list for sales since 1993, when SoundScan began current tracking methods.
Carly Rae Jepsen's Call Me Maybe was behind Gotye at 6.5 million. Both songs are the first to cross the six million digital sales mark, while fun. came close with 5.9 million downloads of We Are Young, featuring Janelle Monae.
Forty-one songs crossed the two million download mark, helping drive digital and overall sales to a new high even as album sales began to drop again after a momentary gain.
One Direction nearly matched Swift's sales total, but did it by placing two 2012 releases in the top 10 - Up All Night placed at No 3 with 1.6 million sold and Take Me Home was fifth with 1.3 million.
Mumford & Son's Babel was at No 6 (1.4 million) and Justin Bieber's Believe (1.3 million) round out the top 10. Only 10 albums reached one million in sales. And Katy Perry received the most radio airplay for the second year in a row with 1.4 million spins, while Swift was the most streamed artist at 216 million streams.