Nelson gave away the points with a series of disastrous mistakes at St Helens.
Less than two minutes had elapsed when Billy Carrington allowed Iain Dyson's shot to slip from his grasp and juggled the ball into the roof of his own net.
Despite the setback, the Blues equalised on 27 minutes when Mark Banyards' superb diagonal pass released Carl Turner who forced a low shot into the goal.
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Nelson's joy was short-lived as, within a minute, Paul Cliff's high lob caught out Carrington who could only punch the ball into his own net.
Karl Ledsham increased St Helens' lead five minutes before half-time when the Blues defence appealed in vain for off-side.
In the second-half, Nelson dominated the game with the strong wind up their backs, but Lee Barrett's goal' was ruled out.
The Blues defence was at fault as Rob Whyte scored a fourth for St Helens on 75 minutes.
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