Barnoldswick Town are at home to Glossop and are hot on the heels of Ramsbottom.
Colne are also having a good season and welcome Runcorn Linnets to Holt House.
The in-form Paul Fildes bagged a brace as Padiham drew at Flixton in midweek and go to Maine Road.
Bacup Borough drew 0-0 with the Manchester outfit on Wednesday – but can do Ramsbottom a favour against New Mills at West View.
Darwen are at home to Chadderton in the First Division.
Vodkat League Premier Division: Alsager v Ramsbottom U, Ashton A v St Helens T, Bacup v New Mills, Barnoldswick v Glossop, Bootle v Squires G, Colne v Runcorn, Flixton v Atherton, Maine Rd v Padiham, Rossendale U v Formby, Stone D v Silsden, Winsford U v Congleton.
Vodkat League First Division: Abbey H v Ashton T, AFC Blackpool v Daisy Hill, Darwen v Chadderton, Atherton Collieries v AFC Liverpool, Eccleshall v Oldham Boro, Holker OB v Runcorn T, Leek CSOB v Irlam, Wigan RP v Cheadle T.
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